Article
The rate of spontaneous mutations in yeast deficient for MutSβ function.
G3 (Bethesda, Md.) - 9 Mar 2023
Plavskin Yevgeniy, de Biase Maria Stella, Schwarz Roland F, Siegal Mark L
Abstract excerpt
Mutations in simple sequence repeat loci underlie many inherited disorders in humans, and are increasingly recognized as important determinants of natural phenotypic variation. In eukaryotes, mutations in these sequences are primarily repaired by the MutSβ mismatch repair complex. To better understand the role of this complex in mismatch repair and the determinants of simple sequence repeat mutation...
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