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Article

Differential stability and trade-off effects of pathoadaptive mutations in the Escherichia coli FimH adhesin.

Infection and immunity - 1 Jul 2007

Weissman Scott J, Beskhlebnaya Viktoriya, Chesnokova Veronika, Chattopadhyay Sujay, Stamm Walter E, Hooton Thomas M, Sokurenko Evgeni V

Abstract excerpt

FimH is the tip adhesin of mannose-specific type 1 fimbriae of Escherichia coli, which are critical to the pathogenesis of urinary tract infections. Point FimH mutations increasing monomannose (1M)-specific uroepithelial adhesion are commonly found in uropathogenic strains of E. coli. Here, we demonstrate the emergence of a mixed population of clonally identical E. coli strains in the urine of a patient with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17502398
DOI: 10.1128/IAI.01963-06
PMCID: PMC1932922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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