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Article

The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target?

Chembiochem : a European journal of chemical biology - 2 Jun 2016

Eris Deniz, Preston Roland C, Scharenberg Meike, Hulliger Fabian, Abgottspon Daniela, Pang Lijuan, Jiang Xiaohua, Schwardt Oliver, Ernst Beat

Abstract excerpt

FimH is a bacterial lectin found at the tips of type 1 pili of uropathogenic Escherichia coli (UPEC). It mediates shear-enhanced adhesion to mannosylated surfaces. Binding of UPEC to urothelial cells initiates the infection cycle leading to urinary tract infections (UTIs). Antiadhesive glycomimetics based on α-d-mannopyranose offer an attractive alternative to the conventional antibiotic treatment because they do...

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Identifiers

PMID: 26991759
DOI: 10.1002/cbic.201600066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Conformational Variability of FimH: Which Conformation Represents the Therapeutic Target?PMID 26991759Read ↗

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