Article
Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Sokurenko E V, Chesnokova V, Dykhuizen D E, Ofek I, Wu X R, Krogfelt K A, Struve C, Schembri M A, Hasty D L
Abstract excerpt
Conventional wisdom regarding mechanisms of bacterial pathogenesis holds that pathogens arise by external acquisition of distinct virulence factors, whereas determinants shared by pathogens and commensals are considered to be functionally equivalent and have been ignored as genes that could becom...
Topics
- Adhesins, Bacterial
- Adhesins, Escherichia coli
- Alleles
- Amino Acid Sequence
- Animals
- Bacterial Adhesion
- Escherichia coli
- Female
- Fimbriae Proteins
- Guinea Pigs
- Mice
- Mice, Inbred C3H
- Molecular Sequence Data
- Mutation
- Phenotype