Article
Pathogenic adaptation of Escherichia coli by natural variation of the FimH adhesin.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Sokurenko E V, Chesnokova V, Dykhuizen D E, Ofek I, Wu X R, Krogfelt K A, Struve C, Schembri M A, Hasty D L
Abstract excerpt
Conventional wisdom regarding mechanisms of bacterial pathogenesis holds that pathogens arise by external acquisition of distinct virulence factors, whereas determinants shared by pathogens and commensals are considered to be functionally equivalent and have been ignored as genes that could become adapted specifically for virulence. It is shown here, however, that genetic variation in an originally commensal...
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