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Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis

17 Sept 2024

Abstract excerpt

Klebsiella pneumoniae is an important pathogen causing difficult-to-treat urinary tract infections (UTIs). Over 1.5 million women per year suffer from recurrent UTI, reducing quality of life and causing substantial morbidity and mortality, especially in the hospital setting. Uropathogenic E. coli (UPEC) is the most prevalent cause of UTI. Like UPEC, K. pneumoniae relies on type 1 pili, tipped with the...

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PMID: 39288182
DOI: 10.1073/pnas.2409655121

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