Article
Comparative structure-function analysis of mannose-specific FimH adhesins from Klebsiella pneumoniae and Escherichia coli.
Journal of bacteriology - 1 Nov 2009
Stahlhut Steen G, Tchesnokova Veronika, Struve Carsten, Weissman Scott J, Chattopadhyay Sujay, Yakovenko Olga, Aprikian Pavel, Sokurenko Evgeni V, Krogfelt Karen Angeliki
Abstract excerpt
FimH, the adhesive subunit of type 1 fimbriae expressed by many enterobacteria, mediates mannose-sensitive binding to target host cells. At the same time, fine receptor-structural specificities of FimH from different species can be substantially different, affecting bacterial tissue tropism and, as a result, the role of the particular fimbriae in pathogenesis. In this study, we compared functional properties of...
Topics
- Adhesins, Escherichia coli
- Escherichia coli
- Fimbriae Proteins
- Gene Expression Regulation, Bacterial
- Klebsiella pneumoniae
- Mannose
- Models, Molecular
- Mutation
- Polymorphism, Genetic
- Protein Conformation