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Article

Two DNAzymes targeting the telomerase mRNA with large difference in Mg2+ concentration for maximal catalytic activity.

The international journal of biochemistry & cell biology - 1 Jan 2007

Yuan Bi-Feng, Xue Yong, Luo Man, Hao Yu-Hua, Tan Zheng

Abstract excerpt

The 10-23 RNA-cleaving DNAzymes require divalent metal ions, preferentially Mg(2+), for catalytic activity. For intracellular applications, it is important that a DNAzyme can perform maximal cleavage at physiological concentration of Mg(2+) (0.2-2mM). We designed DNAzymes targeting the mRNA of hu...

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Identifiers

PMID: 17499543
DOI: 10.1016/j.biocel.2007.03.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17499543-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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