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Article

An allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities.

The FEBS journal - 1 Jun 2010

Jiang Dazhi, Xu Jiacui, Sheng Yongjie, Sun Yanhong, Zhang Jin

Abstract excerpt

A series of RNA-cleaving or DNA-cleaving DNAzymes have been obtained by in vitro selection. However, engineering an allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities is very challenging. We used an in vitro-selected pistol-like (PL) DNAzyme as a DNA scaffold for designing a DNAzyme with dual catalytic activities. We prepared the 46-nucleotide DNAzyme with DNA-cleaving activity (PL DNAzyme),...

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Source

Identifiers

PMID: 20553490
DOI: 10.1111/j.1742-4658.2010.07669.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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