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Article

Metal ion as both a cofactor and a probe of metal-binding sites in a uranyl-specific DNAzyme: a uranyl photocleavage study.

Nucleic acids research - 1 Nov 2013

Cepeda-Plaza Marjorie, Null Eric L, Lu Yi

Abstract excerpt

DNAzymes are known to bind metal ions specifically to carry out catalytic functions. Despite many studies since DNAzymes were discovered nearly two decades ago, the metal-binding sites in DNAzymes are not fully understood. Herein, we adopt uranyl photocleavage to probe specific uranyl-binding sites in the 39E DNAzyme with catalytically relevant concentrations of uranyl. The results indicate that uranyl binds...

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Identifiers

PMID: 23939617
DOI: 10.1093/nar/gkt694
PMCID: PMC3814387

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