Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides.

Communications biology - 16 Feb 2021

Inomata Rika, Zhao Jing, Miyagishi Makoto

Abstract excerpt

Although several DNAzymes are known, their utility is limited by a narrow range of substrate specificity. Here, we report the isolation of two zinc-dependent DNAzymes, ZincDz1 and ZincDz2, which exhibit compact catalytic core sequences with highly versatile hydrolysis activity. They were selected through in vitro selection followed by deep sequencing analysis. Despite their sequence similarity, each DNAzyme...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Catalytic
Share to Hydrolysis
Share to Kinetics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MicroRNAs

Share to Mutation

Share to Ribonucleotides

Share to Substrate Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 33594202
DOI: 10.1038/s42003-021-01738-6
PMCID: PMC7886857

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zn2+-dependent DNAzymes that cleave all combinations of ribonucleotides.PMID 33594202Read ↗

Chemical evolution of an autonomous DNAzyme with allele-specific gene silencing activity.Semantic proximity Read ↗

Functional compromises among pH tolerance, site specificity, and sequence tolerance for a DNA-hydrolyzing deoxyribozyme.Semantic proximity Read ↗

A new and efficient DNA enzyme for the sequence-specific cleavage of RNA.Semantic proximity Read ↗

Detection of single-base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation.Semantic proximity Read ↗

Rational design yields RNA-binding zinc finger domains with altered sequence specificity.Semantic proximity Read ↗

Characterizing the secondary structure and identifying functionally essential nucleotides of pH6DZ1, a fluorescence-signaling and RNA-cleaving deoxyribozyme.Semantic proximity Read ↗

An allosteric DNAzyme with dual RNA-cleaving and DNA-cleaving activities.Semantic proximity Read ↗

Assistant deoxyribonucleic acid recycling with Zn(2+) and molecular beacon for electrochemical detection of deoxyribonucleic acid via target-triggered assembly of mutated DNAzyme.Semantic proximity Read ↗

Design, construction and in vitro testing of zinc finger nucleasesSemantic proximity Read ↗

Guiding-Strand-Controlled DNA Nucleases with Enhanced Specificity and Tunable Kinetics for DNA Mutation Detection.Semantic proximity Read ↗

Thirty-five years of research into ribozymes and nucleic acid catalysis: where do we stand today?Semantic proximity Read ↗

Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.