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Article

Quantitative studies of Mn(2+)-promoted specific and non-specific cleavages of a large RNA: Mn(2+)-GAAA ribozymes and the evolution of small ribozymes.

Nucleic acids research - 1 Nov 2000

Kuo T C, Herrin D L

Abstract excerpt

Manganese (Mn(2+)) promotes specific cleavage at two major (I and III) and four minor (II, IV, V and VI) sites, in addition to slow non-specific cleavage, in a 659-nucleotide RNA containing the Cr.LSU group I intron. The specific cleavages occurred between G and AAA sequences and thus can be considered Mn(2+)-GAAA ribozymes. We have estimated rates of specific and non-specific cleavages under different...

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Identifiers

PMID: 11058117
DOI: 10.1093/nar/28.21.4197
PMCID: PMC113148

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Source receipt: pubmed, retrieved 7 Sept 2026.

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