Article
Long terminal repeat sequences from virulent and attenuated equine infectious anemia virus demonstrate distinct promoter activities.
Virus research - 1 Sept 2007
Zhou Tao, Yuan Xiu-Fang, Hou Shao-Hua, Tu Ya-Bin, Peng Jin-Mei, Wen Jian-Xin, Qiu Hua-Ji, Wu Dong-Lai, Chen Huan-Chun, Wang Xiao-Jun, Tong Guang-Zhi
Abstract excerpt
In the early 1970s, the Chinese Equine Infectious Anemia Virus (EIAV) vaccine, EIAV(DLA), was developed through successive passages of a wild-type virulent virus (EIAV(L)) in donkeys in vivo and then in donkey macrophages in vitro. EIAV attenuation and cell tropism adaptation are associated with changes in both envelope and long terminal repeat (LTR). However, specific LTR changes during Chinese EIAV attenuation...
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