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Amino acid mutations of the infectious clone from Chinese EIAV attenuated vaccine resulted in reversion of virulence.

Vaccine - 6 Feb 2006

Shen Tao, Liang Hua, Tong Xiao, Fan Xiujuan, He Xiang, Ma Yan, Xiang Wenhua, Shen Rongxian, Zhang Xiaoyan, Shao Yiming

Abstract excerpt

The Chinese equine infectious anemia virus (EIAV) donkey-leukocyte attenuated vaccine (DLV) provides a unique natural model system by which attenuated mechanism and immunological control of lentivirus replication may be studied. We analyzed the critical consensus mutations that occurred during the viral passages in vitro and in vivo for vaccine's preparation. Based on the full-length infectious clone pLGFD3 (EIAV...

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Source

Identifiers

PMID: 16202485
DOI: 10.1016/j.vaccine.2005.08.084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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