Article
Effects of long terminal repeat sequence variation on equine infectious anemia virus replication in vitro and in vivo.
Virology - 25 Oct 1999
Lichtenstein D L, Craigo J K, Leroux C, Rushlow K E, Cook R F, Cook S J, Issel C J, Montelaro R C
Abstract excerpt
The long terminal repeat (LTR) is reported to be one of the most variable portions of the equine infectious anemia virus (EIAV) genome. To date, however, no information is available on the effects of observed sequence variations on viral replication properties, despite a widespread assumption of the biological importance of EIAV LTR variation. EIAV LTR sequence variability is confined mostly to a small portion of...
Topics
- Animals
- Base Sequence
- Cell Line
- Enhancer Elements, Genetic
- Equine Infectious Anemia
- Fibroblasts
- Genetic Variation
- Horses
- Infectious Anemia Virus, Equine
- Macrophages
- Molecular Sequence Data
- Mutation
- RNA, Viral