Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice.

Oncogene - 24 Jul 2003

Rose-Hellekant Teresa A, Arendt Lisa M, Schroeder Matthew D, Gilchrist Kennedy, Sandgren Eric P, Schuler Linda A

Abstract excerpt

The role of prolactin in human breast cancer has been controversial. However, it is now apparent that human mammary epithelial cells can synthesize prolactin endogenously, permitting autocrine/paracrine actions within the mammary gland that are independent of pituitary prolactin. To model this local mammary production of prolactin (PRL), we have generated mice that overexpress prolactin within mammary epithelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bromodeoxyuridine
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lipocalin-2

Share to Lipocalins

Share to Mammary Neoplasms, Animal

Share to Prolactin

Share to Receptors, Estrogen

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 12879011
DOI: 10.1038/sj.onc.1206619
PMCID: PMC1630768

Genes

NRL
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prolactin induces ERalpha-positive and ERalpha-negative mammary cancer in transgenic mice.PMID 12879011Read ↗

Mammary tumor phenotypes in wild-type aging female FVB/N mice with pituitary prolactinomas.Semantic proximity Read ↗

Breast Cancer and Prolactin – New Mechanisms and ModelsSemantic proximity Read ↗

Prolactin activates ERα in the absence of ligand in female mammary development and carcinogenesis in vivo.Semantic proximity Read ↗

Prolactin and human tumourogenesis.Semantic proximity Read ↗

A Spontaneous Aggressive ERα+ Mammary Tumor Model Is Driven by Kras ActivationSemantic proximity Read ↗

Molecular pathogenesis of human prolactinomas identified by gene expression profiling, RT-qPCR, and proteomic analysesSemantic proximity Read ↗

Spontaneous aggressive ERα+ mammary tumor model is driven by Kras activationSemantic proximity Read ↗

Hypothesis Prolactin is tumorigenic to human breast: dispelling the myth that prolactin‐induced mammary tumors are rodent‐specificSemantic proximity Read ↗

Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis.Semantic proximity Read ↗

A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation.Semantic proximity Read ↗

Expression by transgenesis of a constitutively active mutant form of the prolactin receptor induces premature abnormal development of the mouse mammary gland and lactation failure.Semantic proximity Read ↗

The Role of Prolactin in Mammary CarcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.