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Article

FOXA1 is an essential determinant of ERα expression and mammary ductal morphogenesis

25 May 2010

Abstract excerpt

FOXA1, estrogen receptor alpha (ERalpha) and GATA3 independently predict favorable outcome in breast cancer patients, and their expression correlates with a differentiated, luminal tumor subtype. As transcription factors, each functions in the morphogenesis of various organs, with ERalpha and GATA3 being established regulators of mammary gland development. Interdependency between these three factors in breast...

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PMID: 20501593
DOI: 10.1242/dev.043299

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