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Article

Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis.

Cancer research - 15 May 2004

Lin Suh-Chin J, Lee Kuo-Fen, Nikitin Alexander Yu, Hilsenbeck Susan G, Cardiff Robert D, Li Aihua, Kang Keon-Wook, Frank Steven A, Lee Wen-Hwa, Lee Eva Y-H P

Abstract excerpt

Approximately 70% of human breast cancers are estrogen receptor alpha (ERalpha)-positive, but the origins of ERalpha-positive and -negative tumors remain unclear. Hormonal regulation of mammary gland development in mice is similar to that in humans; however, most mouse models produce only ERalpha-negative tumors. In addition, these mouse tumors metastasize at a low rate relative to human breast tumors. We report...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15150107
DOI: 10.1158/0008-5472.CAN-03-3524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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