Article
Unliganded estrogen receptor alpha inhibits breast cancer cell growth through interaction with a cyclin-dependent kinase inhibitor (p21(WAF1)).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2008
Maynadier Marie, Ramirez Jean-Marie, Cathiard Anne-Marie, Platet Nadine, Gras Delphine, Gleizes Michel, Sheikh M Saeed, Nirde Philippe, Garcia Marcel
Abstract excerpt
Estrogens are mitogenic in human breast cancer cells, but the presence of estrogen receptor alpha (ER alpha) is associated with a favorable prognosis in primary tumors and the molecular basis for this paradoxical relationship remains unknown. Here we show that ER alpha and ER alpha mutants devoid of ligand and DNA-binding domains inhibit cell growth in three-dimensional matrix as well as tumor formation in nude...
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