Article
Circulating level of sPD-1 and PD-1 genetic variants are associated with hepatitis B infection and related liver disease progression.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Feb 2022
Huyen Pham Thi Minh, Dung Dang Thi Ngoc, Weiß Peter Johann, Hoan Phan Quoc, Giang Dao Phuong, Uyen Ngo Thi, Van Tuan Nguyen, Trung Ngo Tat, Velavan Thirumalaisamy P, Song Le Huu, Hoan Nghiem Xuan
Abstract excerpt
BACKGROUND: Programmed cell death-1 (PD-1) variants and circulating level of soluble PD-1 are associated with susceptibility to malignant and infectious disease. This study aimed to examine the association of PD-1.5 and PD-1.9 variants, and plasma sPD-1 level with hepatitis B virus (HBV) infection and disease progression. METHODS: The study cohort consisted of adults infected with HBV (n=513) - stratified by...
Topics
- Carcinoma, Hepatocellular
- Case-Control Studies
- Disease Progression
- Genetic Predisposition to Disease
- Hepatitis B
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Programmed Cell Death 1 Receptor