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Article

Potentially functional genetic variants in RPS6KA4 and MAP2K5 in the MAPK signaling pathway predict HBV-related hepatocellular carcinoma survival.

Molecular carcinogenesis - 1 Sept 2023

Qiu Moqin, Lin Qiuling, Liu Yingchun, Chen Peiqin, Zhou Yunxiang, Jiang Yanji, Zhou Zihan, Wen Qiuping, Zhou Xianguo, Liang Xiumei, Gan Haijie, Yu Hongping

Abstract excerpt

Hepatocellular carcinoma (HCC) ranks the third leading cause of cancer deaths with a dismal 5-year survival rate. The mitogen-activated protein kinase (MAPK) signaling pathway is abnormally activated in HCC to promote growth and aggressive metastatic potential of cancer cells. Therefore, genetic variants in the MAPK signaling pathway may serve as potential predictors of Hepatitis B virus (HBV)-related HCC...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 37278562
DOI: 10.1002/mc.23583

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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