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Article

P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine.

Drug metabolism and pharmacokinetics - 1 Apr 2007

Benetton Salete A, Fang Che, Yang Yan-ou, Alok Ramya, Year Mey, Lin Chin-Chung, Yeh Li-Tain

Abstract excerpt

Although there is evidence in the literature of the participation of CYP2B6 in the metabolism of selegiline, it is not clear which other CYP isoforms contribute to its metabolism. The aim of this study was to investigate the P450 isozymes (CYPs) involved in the metabolism of selegiline to desmethylselegiline (DMS) and methamphetamine (MA) using four assays: incubation of selegiline with cDNA expressed CYPs,...

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Source

Identifiers

PMID: 17495414
DOI: 10.2133/dmpk.22.78

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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