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Identification of human cytochrome P450 2D6 as major enzyme involved in the O-demethylation of the designer drug p-methoxymethamphetamine.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2004

Staack Roland F, Theobald Denis S, Paul Liane D, Springer Dietmar, Kraemer Thomas, Maurer Hans H

Abstract excerpt

p-Methoxymethamphetamine (PMMA) is a new designer drug, listed in many countries as a controlled substance. Several fatalities have been attributed to the abuse of this designer drug. Previous in vivo studies using Wistar rats had shown that PMMA was metabolized mainly by O-demethylation. The aim of the study presented here was to identify the human hepatic cytochrome P450 (P450) enzymes involved in the...

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PMID: 15039289
DOI: 10.1124/dmd.32.4.379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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