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Article

Dasotraline as a selective cytochrome 2B6 inhibitor for reaction phenotyping.

Biopharmaceutics & drug disposition - 1 Nov 2019

Yang Xin, Ryu Sangwoo, Di Li

Abstract excerpt

Reaction phenotyping using human liver microsomes or hepatocytes with chemical inhibitors is one of the most commonly applied methods to assess the fraction metabolized (fm ) of drug candidates by enzymes. The fm information is critical to understanding the risk of victim drug-drug interactions in the clinic. Inhibitor selectivity is essential in order to generate reliable data and irreversible inhibitors are...

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PMID: 31674039
DOI: 10.1002/bdd.2207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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