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Article

Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2003

Evans David C, O'Connor Desmond, Lake Brian G, Evers Raymond, Allen Christopher, Hargreaves Richard

Abstract excerpt

"Reaction phenotyping" studies were performed with eletriptan (ETT) to determine its propensity to interact with coadministered medications. Its ability to serve as a substrate for human P-glycoprotein (P-gp) was also investigated since a central mechanism of action has been proposed for this "tr...

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Source

Identifiers

PMID: 12814962
DOI: 10.1124/dmd.31.7.861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12814962-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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