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Article

The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver.

British journal of clinical pharmacology - 1 Aug 2002

Coller Janet K, Krebsfaenger Niels, Klein Kathrin, Endrizzi Karin, Wolbold Renzo, Lang Thomas, Nüssler Andreas, Neuhaus Peter, Zanger Ulrich M, Eichelbaum Michel, Mürdter Thomas E

Abstract excerpt

AIMS: To investigate in a large panel of 50 human liver samples the contribution of CYP2C9, CYP2D6, and CYP3A4 to the overall formation of the potent antioestrogen Z-4-hydroxy-tamoxifen, and how various genotypes affect its formation from tamoxifen. METHODS: The formation of Z-4-hydroxy-tamoxifen...

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Identifiers

PMID: 12207635
DOI: 10.1046/j.1365-2125.2002.01614.x
PMCID: PMC1874408

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12207635-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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