Article
Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2001
Sproule T J, Jazwinska E C, Britton R S, Bacon B R, Fleming R E, Sly W S, Roopenian D C
Abstract excerpt
Hereditary hemochromatosis (HH) is a common chronic human genetic disorder whose hallmark is systemic iron overload. Homozygosity for a mutation in the MHC class I heavy chain paralogue gene HFE has been found to be a primary cause of HH. However, many individuals homozygous for the defective allele of HFE do not develop iron overload, raising the possibility that genetic variation in modifier loci contributes to...
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