Article
Genetic resistance to diet-induced obesity in chromosome substitution strains of mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2010
Burrage Lindsay C, Baskin-Hill Annie E, Sinasac David S, Singer Jonathan B, Croniger Colleen M, Kirby Andrew, Kulbokas E J, Daly Mark J, Lander Eric S, Broman Karl W, Nadeau Joseph H
Abstract excerpt
Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr(A/J)/NaJ panel of chromosome substitution strains (CSSs) is a unique model for studying resistance to diet-induced obesity. In the present study, three replicate CSS surveys showed remarkable consistency, with 13 A/J-derived chromosomes...
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