Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.

Abstract excerpt

Beta1-integrins are cell surface receptors that participate in sensing the cell's external environment. We used the Cre-lox system to delete beta1-integrin in all lens cells as the lens vesicle transitions into the lens. Adult mice lacking beta1-integrin in the lens are microphthalmic due to apoptosis of the lens epithelium and neonatal disintegration of the lens fibers. The first morphological alterations in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Crystallins
• Share to Epithelium