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Article

Conditional deletion of beta1-integrin from the developing lens leads to loss of the lens epithelial phenotype.

Developmental biology - 15 Jun 2007

Simirskii Vladimir N, Wang Yan, Duncan Melinda K

Abstract excerpt

Beta1-integrins are cell surface receptors that participate in sensing the cell's external environment. We used the Cre-lox system to delete beta1-integrin in all lens cells as the lens vesicle transitions into the lens. Adult mice lacking beta1-integrin in the lens are microphthalmic due to apop...

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Identifiers

PMID: 17493607
DOI: 10.1016/j.ydbio.2007.04.004
PMCID: PMC1950782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17493607-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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