Identification and molecular characterization of multiple phenotypes in integrin knockout mice.

doi:10.1016/S0076-6879(07)26013-6

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Article

Identification and molecular characterization of multiple phenotypes in integrin knockout mice.

Methods in enzymology - 1 Jan 2007

Chen Chun, Sheppard Dean

Abstract excerpt

Each of the 24 known integrin subunits has now been inactivated in mice, and a growing number of conditional null lines are becoming available. Lines of mice expressing null mutations in integrin subunit genes have taught us a great deal about the remarkably diverse functions that integrins perform in vivo in mammals. Thorough evaluation of the phenotypes manifested by these lines has also revealed a number of...

Topics

Animals
Integrins
Mice
Mice, Knockout
Molecular Biology
Phenotype

Source

Open in PubMed

Identifiers

PMID: 17697889
DOI: 10.1016/S0076-6879(07)26013-6

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