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Article

Nutrient availability as a mechanism for selection of antibiotic tolerant Pseudomonas aeruginosa within the CF airway.

PLoS pathogens - 8 Jan 2010

Hoffman Lucas R, Richardson Anthony R, Houston Laura S, Kulasekara Hemantha D, Martens-Habbena Willm, Klausen Mikkel, Burns Jane L, Stahl David A, Hassett Daniel J, Fang Ferric C, Miller Samuel I

Abstract excerpt

Microbes are subjected to selective pressures during chronic infections of host tissues. Pseudomonas aeruginosa isolates with inactivating mutations in the transcriptional regulator LasR are frequently selected within the airways of people with cystic fibrosis (CF), and infection with these isolates has been associated with poorer lung function outcomes. The mechanisms underlying selection for lasR mutation are...

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Identifiers

PMID: 20072604
DOI: 10.1371/journal.ppat.1000712
PMCID: PMC2795201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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