Article
p53: an overview of over two decades of study.
The Malaysian journal of pathology - 1 Jun 2001
Cheah P L, Looi L M
Abstract excerpt
p53 is the most commonly mutated gene in human cancers. It encodes a 53 kilodalton protein with several evolutionarily conserved domains viz sequence-specific DNA binding, tetramerisation, SH3 molecule binding, C-terminal and N-terminal. Existing in the cell at a very low level and in a relatively inactive form, p53 protein is increased and activated during periods of cellular stress. Unlike other proteins, the...
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