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Article

Role of p53 in breast cancer progression: An insight into p53 targeted therapy.

Theranostics - 1 Jan 2023

Marvalim Charlie, Datta Arpita, Lee Soo Chin

Abstract excerpt

The transcription factor p53 is an important regulator of a multitude of cellular processes. In the presence of genotoxic stress, p53 is activated to facilitate DNA repair, cell cycle arrest, and apoptosis. In breast cancer, the tumor suppressive activities of p53 are frequently inactivated by either the overexpression of its negative regulator MDM2, or mutation which is present in 30-35% of all breast cancer...

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Identifiers

PMID: 36923534
DOI: 10.7150/thno.81847
PMCID: PMC10008729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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