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Role of p53 Gene in Breast Cancer: Focus on Mutation Spectrum and Therapeutic Strategies

26 Sept 2018

Abstract excerpt

TP53 is a tumor suppressor gene which is commonly mutated in various cancers including breast cancer. Alterations in the gene lead to an altered expression of various genes that are directly or indirectly under the transcriptional control of p53. This results in malfunctioning of DNA damage repair pathways, cell-cycle arrest, chromatin remodeling and apoptosis. Different mutations in TP53 gene have been reported...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 30255744
DOI: 10.2174/1381612824666180926095709

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