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Article

BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of Hematopoiesis

1 Nov 1999

Abstract excerpt

The BCR/ABL oncogene causes chronic myelogenous leukemia (CML), a myeloproliferative disorder characterized by clonal expansion of hematopoietic progenitor cells and granulocyte lineage cells. The SH2-containing inositol-5-phosphatase SHIP is a 145-kDa protein which has been shown to regulate hematopoiesis in mice. Targeted disruption of the murine SHIP gene results in a myeloproliferative syndrome characterized...

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PMID: 10523635
DOI: 10.1128/mcb.19.11.7473

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BCR/ABL Directly Inhibits Expression of SHIP, an SH2-Containing Polyinositol-5-Phosphatase Involved in the Regulation of HematopoiesisPMID 10523635Read ↗

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JAK2-V617F is a negative regulation factor of SHIP1 protein and thus influences the AKT signaling pathway in patients with Myeloproliferative neoplasm (MPN).Semantic proximity Read ↗

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Induced SHIP Deficiency Expands Myeloid Regulatory Cells and Abrogates Graft-versus-Host DiseaseSemantic proximity Read ↗

Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia.Semantic proximity Read ↗

[Mutation analysis of SHIP gene in acute leukemia].Semantic proximity Read ↗

Downstream of tyrosine kinases-1 and Src homology 2-containing inositol 5'-phosphatase are required for regulation of CD4+CD25+ T cell development.Semantic proximity Read ↗

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