Article
Does strong linkage disequilibrium guarantee redundant association results?
Genetic epidemiology - 1 Sept 2008
Nielsen Dahlia M, Suchindran Sunil, Smith Christopher P
Abstract excerpt
A substantial amount of effort has been expended recently towards the identification and evaluation of tag single nucleotide polymorphisms; markers that, due to linkage disequilibrium (LD) patterns in the genome, are able to act as "proxies" for other polymorphic sites. As such, these tag markers are assumed to capture, on their own, a large proportion of the genetic variation contributed by a much greater number...
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