Article
Integration of somatic deletion analysis of prostate cancers and germline linkage analysis of prostate cancer families reveals two small consensus regions for prostate cancer genes at 8p.
Cancer research - 1 May 2007
Chang Bao-Li, Liu Wennuan, Sun Jishan, Dimitrov Latchezar, Li Tao, Turner Aubrey R, Zheng Siqun L, Isaacs William B, Xu Jianfeng
Abstract excerpt
The evidence for tumor suppressor genes at 8p is well supported by many somatic deletion studies and genetic linkage studies. However, it remains a challenge to pinpoint the tumor suppressor genes at 8p primarily because the implicated regions are broad. In this study, we attempted to narrow down the implicated regions by incorporating evidence from both somatic and germline studies. Using high-resolution...
Topics
- Chromosomes, Human, Pair 8
- Consensus Sequence
- Gene Deletion
- Genetic Linkage
- Humans
- Male
- Microsatellite Repeats
- Middle Aged
- Polymorphism, Single Nucleotide
- Prostatic Neoplasms