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Article

New screening system for selective blockers of voltage-gated K(+) channels using recombinant cell lines dying upon single action potential.

Journal of pharmacological sciences - 1 Jan 2013

Fujii Masato, Hayashi Keisuke, Ohya Susumu, Yamamura Hisao, Imaizumi Yuji

Abstract excerpt

To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively. Electrical stimulation (ES) of a cell line, I...

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Identifiers

PMID: 24096832
DOI: 10.1254/jphs.13063fp

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24096832-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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