Article
Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels.
Molecular pharmacology - 1 Jul 2018
Murayama Takashi, Kurebayashi Nagomi, Ishigami-Yuasa Mari, Mori Shuichi, Suzuki Yukina, Akima Ryunosuke, Ogawa Haruo, Suzuki Junji, Kanemaru Kazunori, Oyamada Hideto, Kiuchi Yuji, Iino Masamitsu, Kagechika Hiroyuki, Sakurai Takashi
Abstract excerpt
Genetic mutations in ryanodine receptors (RyRs), Ca2+-release channels in the sarcoplasmic reticulum essential for muscle contractions, cause various skeletal muscle and cardiac diseases. Because the main underlying mechanism of the pathogenesis is overactive Ca2+ release by gain-of-function of the RyR channel, inhibition of RyRs is expected to be a promising treatment of these diseases. Here, to identify...
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