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Article

Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels.

FEBS letters - 12 Nov 2008

Shcheglovitov Aleksandr, Vitko Iuliia, Bidaud Isabelle, Baumgart Joel P, Navarro-Gonzalez Manuel F, Grayson T Hilton, Lory Philippe, Hill Caryl E, Perez-Reyes Edward

Abstract excerpt

Molecular diversity of T-type/Ca(v)3 Ca2+ channels is created by expression of three genes and alternative splicing of those genes. Prompted by the important role of the I-II linker in gating and surface expression of Ca(v)3 channels, we describe here the properties of a novel variant that partially deletes this loop. The variant is abundantly expressed in rat brain, even exceeding transcripts with the complete...

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Source

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Identifiers

PMID: 18930057
DOI: 10.1016/j.febslet.2008.10.013
PMCID: PMC2614674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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