Article
Experimental models for the autoimmune and inflammatory blistering disease, Bullous pemphigoid.
Archives of dermatological research - 1 Nov 2007
Leighty Lisa, Li Ning, Diaz Luis A, Liu Zhi
Abstract excerpt
Bullous pemphigoid (BP) is a subepidermal skin blistering disease characterized immunohistologically by dermal-epidermal junction (DEJ) separation, an inflammatory cell infiltrate in the upper dermis, and autoantibodies targeted toward the hemidesmosomal proteins BP230 and BP180. Development of an IgG passive transfer mouse model of BP that reproduces these key features of human BP has demonstrated that...
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