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Article

Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice.

Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2006

Sitaru Cassian, Chiriac Mircea T, Mihai Sidonia, Büning Jürgen, Gebert Andreas, Ishiko Akira, Zillikens Detlef

Abstract excerpt

Experimental models reproducing an autoimmune response resulting in skin blistering in immunocompetent animals are lacking. Epidermolysis bullosa acquisita (EBA) is a bullous skin disease caused by autoantibodies to type VII collagen. In this study, we describe an active disease model of EBA by immunizing mice of different strains with murine type VII collagen. All mice developed circulating IgG autoantibodies...

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Source

Identifiers

PMID: 16920988
DOI: 10.4049/jimmunol.177.5.3461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Induction of complement-fixing autoantibodies against type VII collagen results in subepidermal blistering in mice.PMID 16920988Read ↗

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Autoantibodies to type VII collagen have heterogeneous subclass and light chain compositions and their complement-activating capacities do not correlate with the inflammatory clinical phenotype.Semantic proximity Read ↗

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