Article
Identification of quantitative trait loci in experimental epidermolysis bullosa acquisita.
The Journal of investigative dermatology - 1 May 2012
Ludwig Ralf J, Müller Susen, Marques Andreia d C, Recke Andreas, Schmidt Enno, Zillikens Detlef, Möller Steffen, Ibrahim Saleh M
Abstract excerpt
Epidermolysis bullosa acquisita (EBA) is a chronic mucocutaneous autoimmune skin blistering disease. Several lines of evidence underscore the contribution of autoantibodies against type VII collagen (COL7) to the pathogenesis of EBA. Furthermore, EBA susceptibility is associated with the MHC haplotype in patients (HLA-DR2) and in immunization-induced EBA in mice (H2s). The latter study indicated an additional...
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