Article
Complement-fixing anti-type VII collagen antibodies are induced in Th1-polarized lymph nodes of epidermolysis bullosa acquisita-susceptible mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2011
Hammers Christoph M, Bieber Katja, Kalies Kathrin, Banczyk David, Ellebrecht Christoph T, Ibrahim Saleh M, Zillikens Detlef, Ludwig Ralf J, Westermann Jürgen
Abstract excerpt
The environment encountered in secondary lymphoid organs (e.g., lymph nodes) influences the outcome of immune responses. Immunization of mice with type VII collagen, an adhesion protein expressed at the cutaneous basement membrane, induces experimental epidermolysis bullosa acquisita (EBA). In this model, clinical disease is associated with the H2s haplotype of the MHC found in SJL/J mice. Most other strains...
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