Article
IgG antibodies against immunodominant C-terminal epitopes of BP230 do not induce skin blistering in mice.
Human immunology - 1 Apr 2014
Feldrihan Vasile, Licarete Emilia, Florea Florina, Cristea Victor, Popescu Octavian, Sitaru Cassian, Chiriac Mircea Teodor
Abstract excerpt
Bullous pemphigoid, the most common autoimmune blistering disease in Western Europe and the USA is characterized by the presence of circulating and tissue-bound autoantibodies against the hemidesmosomal proteins BP230 and BP180/collagen XVII. After binding to their target antigens at the basement membrane of the dermal-epidermal junction these autoantibodies are thought to trigger an inflammatory cascade...
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