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Article

Cutting edge: Genetic variation in TLR1 is associated with Pam3CSK4-induced effector T cell resistance to regulatory T cell suppression.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2014

Mikacenic Carmen, Schneider Anya, Radella Frank, Buckner Jane H, Wurfel Mark M

Abstract excerpt

TLR play essential roles in the initiation and modulation of immune responses. TLR1/TLR2 heterodimers recognize triacylated bacterial lipopeptides, including the synthetic TLR1/2 lipopeptide Pam3CSK4. Genetic variation in TLR1 is associated with outcomes in diseases in which regulatory T cells (Treg) play a role, including asthma and allergy. To determine whether genetic polymorphisms in TLR1 are associated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25378593
DOI: 10.4049/jimmunol.1401185
PMCID: PMC4258445

Genes

TLR1
STAT3
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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