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Article

RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.

Genes & development - 1 May 2007

Sandell Lisa L, Sanderson Brian W, Moiseyev Gennadiy, Johnson Teri, Mushegian Arcady, Young Kendra, Rey Jean-Philippe, Ma Jian-xing, Staehling-Hampton Karen, Trainor Paul A

Abstract excerpt

Regulation of patterning and morphogenesis during embryonic development depends on tissue-specific signaling by retinoic acid (RA), the active form of Vitamin A (retinol). The first enzymatic step in RA synthesis, the oxidation of retinol to retinal, is thought to be carried out by the ubiquitous or overlapping activities of redundant alcohol dehydrogenases. The second oxidation step, the conversion of retinal to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17473173
DOI: 10.1101/gad.1533407
PMCID: PMC1855236

Genes

RDH10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.PMID 17473173Read ↗

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Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.Semantic proximity Read ↗

Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina.Semantic proximity Read ↗

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Ethanol induces embryonic malformations by competing for retinaldehyde dehydrogenase activity during vertebrate gastrulation.Semantic proximity Read ↗

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