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Article

Rdh12 activity and effects on retinoid processing in the murine retina.

The Journal of biological chemistry - 7 Aug 2009

Chrispell Jared D, Feathers Kecia L, Kane Maureen A, Kim Chul Y, Brooks Matthew, Khanna Ritu, Kurth Ingo, Hübner Christian A, Gal Andreas, Mears Alan J, Swaroop Anand, Napoli Joseph L, Sparrow Janet R, Thompson Debra A

Abstract excerpt

RDH12 mutations are responsible for early-onset autosomal recessive retinal dystrophy, which results in profound retinal pathology and severe visual handicap in patients. To investigate the function of RDH12 within the network of retinoid dehydrogenases/reductases (RDHs) present in retina, we studied the retinal phenotype of Rdh12-deficient mice. In vivo rates of all-trans-retinal reduction and 11-cis-retinal...

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Identifiers

PMID: 19506076
DOI: 10.1074/jbc.M109.020966
PMCID: PMC2755871

Genes

RDH12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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