Characterization of key residues and membrane association domains in retinol dehydrogenase 10.

doi:10.1042/BJ20080812

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Article

Characterization of key residues and membrane association domains in retinol dehydrogenase 10.

The Biochemical journal - 1 Apr 2009

Takahashi Yusuke, Moiseyev Gennadiy, Farjo Krysten, Ma Jian-Xing

Abstract excerpt

RDH10 (retinol dehydrogenase 10) was originally identified from the retinal pigment epithelium and retinal Müller cells. It has retinoid oxidoreductase activity and is thought to play a role in the retinoid visual cycle. A recent study showed that RDH10 is essential for generating retinoic acid at early embryonic stages. The present study demonstrated that wild-type RDH10 catalysed both oxidation of...

Topics

Alcohol Oxidoreductases
Amino Acid Sequence
Animals
Blotting, Western
COS Cells
Cell Membrane
Chlorocebus aethiops
Humans
Mice
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Protein Structure, Tertiary
Rats
Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 19102727
DOI: 10.1042/BJ20080812
PMCID: PMC2728083

Genes

RDH10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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