Article
Characterization of key residues and membrane association domains in retinol dehydrogenase 10.
The Biochemical journal - 1 Apr 2009
Takahashi Yusuke, Moiseyev Gennadiy, Farjo Krysten, Ma Jian-Xing
Abstract excerpt
RDH10 (retinol dehydrogenase 10) was originally identified from the retinal pigment epithelium and retinal Müller cells. It has retinoid oxidoreductase activity and is thought to play a role in the retinoid visual cycle. A recent study showed that RDH10 is essential for generating retinoic acid at early embryonic stages. The present study demonstrated that wild-type RDH10 catalysed both oxidation of...
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