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Redundant and unique roles of retinol dehydrogenases in the mouse retina

28 Nov 2007

Abstract excerpt

Highly abundant short-chain alcohol dehydrogenases (RDHs) in the retina were assumed to be involved in the recycling of 11-cis-retinal chromophore in the visual cycle. Mutations in human RDH genes are associated with Fundus albipunctatus, a mild form of night blindness (RDH5) and an autosomal recessive, childhood-onset severe retinal dystrophy (RDH12). Rdh12 knockout mice were found to be susceptible to...

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PMID: 18048336
DOI: 10.1073/pnas.0707477104

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Redundant and unique roles of retinol dehydrogenases in the mouse retinaPMID 18048336Read ↗

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