Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.

Biochemistry - 29 Nov 2016

Hofmann Lukas, Tsybovsky Yaroslav, Alexander Nathan S, Babino Darwin, Leung Nicole Y, Montell Craig, Banerjee Surajit, von Lintig Johannes, Palczewski Krzysztof

Abstract excerpt

The 11-cis-retinylidene chromophore of visual pigments isomerizes upon interaction with a photon, initiating a downstream cascade of signaling events that ultimately lead to visual perception. 11-cis-Retinylidene is regenerated through enzymatic transformations collectively called the visual cycle. The first and rate-limiting enzymatic reaction within this cycle, i.e., the reduction of all-trans-retinal to...

Topics

Alcohol Oxidoreductases
Animals
Crystallization
Crystallography, X-Ray
Drosophila Proteins
Drosophila melanogaster
Genetic Complementation Test
Humans
Models, Molecular
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NAD

Oxidoreductases

Protein Binding

Protein Conformation

Protein Multimerization

Source

Open in PubMed Open full text

Identifiers

PMID: 27809489
DOI: 10.1021/acs.biochem.6b00907
PMCID: PMC5154250

Genes

RDH12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural Insights into the Drosophila melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family.PMID 27809489Read ↗

Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function.Semantic proximity Read ↗

Rod and cone visual cycle consequences of a null mutation in the 11-cis-retinol dehydrogenase gene in man.Semantic proximity Read ↗

Characterization of key residues and membrane association domains in retinol dehydrogenase 10.Semantic proximity Read ↗

Retinol dehydrogenase 12 (RDH12): Role in vision, retinal disease and future perspectivesSemantic proximity Read ↗

Retinal Pigment Epitheliopathy due to Sub-Optimal Recycling of Vitamin A (RESORVA): A Novel RDH11 -Related Phenotype.Semantic proximity Read ↗

Focus on molecules: retinol dehydrogenase 12 (RDH12).Semantic proximity Read ↗

Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy.Semantic proximity Read ↗

Dominant <i>RDH12</i> -retinitis pigmentosa impairs photoreceptor development and cone function in retinal organoidsSemantic proximity Read ↗

Redundant and unique roles of retinol dehydrogenases in the mouse retinaSemantic proximity Read ↗

Rdh12 activity and effects on retinoid processing in the murine retina.Semantic proximity Read ↗

Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice.Semantic proximity Read ↗

Retinal degeneration associated with RDH12 mutations results from decreased 11-cis retinal synthesis due to disruption of the visual cycle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.